Clinical Course and Modern Diagnosis of Resistant Forms of Pulmonary Tuberculosis
DOI:
https://doi.org/10.31150/ajshr.v3i2.879Keywords:
resistant form of tuberculosis, pulmonary tuberculosis, clinical course, diagnosis, treatmentAbstract
A survey of 244 patients from the southern regions of the Republic of Uzbekistan was carried out in the period from 2016 to 2020. The age of patients ranged from 18 to 86 years, the average age was 52.1 years, men were 2.2 times more than women. The localization of the tuberculous process in most patients was observed on both lungs - in 89 (36.5%), in 86 (35.2%) - damage to the right lung and less cases of the left lung - in 69 (28.3%) patients. It should be noted that a total lesion of one lung was observed in 51 (20.9%) cases, and a total lesion of both lungs - in 29 (11.9%) patients in whom the clinical manifestation of the disease was severe. Out of 244 patients, in 151 (61.9%) patients, the disease was detected for the first time, and in 93 (38.1%) - again, i.e. they have previously received treatment.
In 239 (97.9%) cases, pulmonary tuberculosis was established by X-ray methods, and the X-ray symptom "Periscissuritis" was often observed - in 74.6% of cases.
Bacterioscopy examination revealed MBT in 154 (63.1%) cases, and 90 (36.9%) cases of MBT were not detected. Sowing of pathological material was carried out on the solid medium of Levenshtein-Jensen - in 229 (93.9%) patients and in 206 (89.9%) cases, growth of colonies of Mycobacterium tuberculosis was noted. And the liquid medium BACTEC MGite 960 - in 15 (6.1%) cases and 11 (73.3%) cases, a positive result was obtained. PCR diagnostics was carried out in the Gene / Xpert device - in 244 (100%) patients and 237 (97.1%) cases, DNA of mycobacterium tuberculosis was detected, and in the HAINtest device - in 164 (67.2%) cases and 100% of cases positive result.
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