The Impact of FGFR4 Gene SNP (Rs 1966265) on the Progression of Colorectal Cancer in Some Iraqi Patients
DOI:
https://doi.org/10.31150/ajshr.v5i6.2807Keywords:
colorectal cancer, single-nucleotide polymorphismAbstract
The high death and prevalence risk of colorectal cancer (CRC) continue to be a worldwide health consequence due to its complex nature. The protein receptor fibroblast expansion element 4 with the aberrant regulatory sequences it activates have been found to have a significant impact on cancer formation and survival. The purpose of this research was to examine the role of FGFR4 genetic polymorphisms in CRC formation and progression. Fifty colorectal cancer cases and fifty non-cancerous controls were analyzed for the FGFR4 SNP. Neither the case nor the control groups showed any discernible SNP-related increase in Cancer risk. Participants with rectal cancer who have at minimum one small mutation of rs1966265 (AG and GG; AOR, 0.256; p = 0.36) become more likely to acquire metastases likened to those with heterozygous for the main allele.
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